Antigen presentation within the cortex. How come good collection crucially determined by one stromal cell typ

Antigen presentation within the cortex. How come good collection crucially determined by one stromal cell typ

During the peak of their output, the mouse thymus every single day builds around fifty million CD4 + CD8 + double good (DP) thymocytes that audition for choice 1 ) A lot more than 90% of the precursors tend to be subject to demise by neglect, while they express a€?uselessa€™ T cell receptors (TCRs) which do not mediate good collection. Good choice of a€?mainstreama€™ I±I? T cells try contingent upon permissive relationships with one APC means, specifically cortical thymic epithelial tissue (cTECs). For conceptual quality, we shall therefore restrict a very detailed discussion of antigen presentation during the cortex to cTECs and their role in positive collection, and can just briefly touch upon negative selection within the cortex at the conclusion of this area.

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